A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer1,212

@inproceedings{Zhao2014ACA,
  title={A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer1,212},
  author={Shuang G. Zhao and Shu-Hao Chang and Jennifer J. Linderman and Felix Feng and Gary D. Luker},
  booktitle={Translational oncology},
  year={2014}
}
CXCL12-CXCR4-CXCR7 signaling promotes tumor growth and metastasis in breast cancer. Alternative splicing of CXCL12 produces isoforms with distinct structural and biochemical properties, but little is known about isoform-specific differences in breast cancer subtypes and patient outcomes. We investigated global expression profiles of the six CXCL12 isoforms, CXCR4, and CXCR7 in The Cancer Genome Atlas breast cancer cohort using next-generation RNA sequencing in 948 breast cancer and benign… CONTINUE READING
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