A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer1,212

  title={A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer1,212},
  author={Shuang G. Zhao and Shu-Hao Chang and Jennifer J. Linderman and Felix Feng and Gary D. Luker},
  booktitle={Translational oncology},
CXCL12-CXCR4-CXCR7 signaling promotes tumor growth and metastasis in breast cancer. Alternative splicing of CXCL12 produces isoforms with distinct structural and biochemical properties, but little is known about isoform-specific differences in breast cancer subtypes and patient outcomes. We investigated global expression profiles of the six CXCL12 isoforms, CXCR4, and CXCR7 in The Cancer Genome Atlas breast cancer cohort using next-generation RNA sequencing in 948 breast cancer and benign… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 15 extracted citations


Publications referenced by this paper.
Showing 1-10 of 63 references

Development and preclinical characterization of a humanized antibody targeting CXCL12.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2013
View 1 Excerpt

PAM50 438 A Comprehensive Analysis of CXCL12 Isoforms

M Martin, A Prat, +7 authors C Davis
Zhao et al. Translational Oncology • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…