A Comprehensive, Quantitative, and Genome-Wide Model of Translation

  title={A Comprehensive, Quantitative, and Genome-Wide Model of Translation},
  author={Marlena Siwiak and Piotr Zielenkiewicz},
  booktitle={PLoS Computational Biology},
Translation is still poorly characterised at the level of individual proteins and its role in regulation of gene expression has been constantly underestimated. To better understand the process of protein synthesis we developed a comprehensive and quantitative model of translation, characterising protein synthesis separately for individual genes. The main advantage of the model is that basing it on only a few datasets and general assumptions allows the calculation of many important translational… CONTINUE READING
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