A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection

@article{Grossman2010ACO,
  title={A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection},
  author={Sharon R Grossman and I. Shlyakhter and E. Karlsson and E. Byrne and Shannon Morales and G. Frieden and E. Hostetter and E. Angelino and M. Garber and O. Zuk and E. Lander and S. Schaffner and Pardis C Sabeti},
  journal={Science},
  year={2010},
  volume={327},
  pages={883 - 886}
}
Pinpointing Genetic Selection The human genome contains hundreds of regions with evidence of recent positive natural selection, yet, for all but a handful of cases, the underlying advantageous mutation remains unknown. Current methods to detect the signal of selection often results in the identification of a broad genomic region containing many candidate regions that vary among individuals. By combining existing statistical methods, Grossman et al. (p. 883, published online 7 January) developed… Expand
442 Citations

Topics from this paper

Detecting and characterizing genomic signatures of positive selection in global populations.
  • 63
Genome wide signals of pervasive positive selection in human evolution
  • 1
  • PDF
Statistical methods for detecting natural selection from genomic data.
  • Y. Suzuki
  • Biology, Medicine
  • Genes & genetic systems
  • 2010
  • 21
  • PDF
Using Population Genomics to Detect Selection in Natural Populations: Key Concepts and Methodological Considerations
  • 156
  • PDF
Detecting recent positive selection with high accuracy and reliability by conditional coalescent tree.
  • 15
  • Highly Influenced
  • PDF
Signatures of positive selection apparent in a small sample of human exomes.
  • 25
  • PDF
Aberrant Time to Most Recent Common Ancestor as a Signature of Natural Selection.
  • 16
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 51 REFERENCES
A Map of Recent Positive Selection in the Human Genome
  • 2,306
  • PDF
Constructing genomic maps of positive selection in humans: where do we go from here?
  • J. Akey
  • Biology, Medicine
  • Genome research
  • 2009
  • 406
  • PDF
Positive Natural Selection in the Human Lineage
  • 988
  • PDF
How reliable are empirical genomic scans for selective sweeps?
  • 369
  • PDF
A second generation human haplotype map of over 3.1 million SNPs
  • 4,315
  • PDF
Molecular genetics of human pigmentation diversity.
  • R. Sturm
  • Biology, Medicine
  • Human molecular genetics
  • 2009
  • 301
  • PDF
ESTIMATING F‐STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE
  • B. Weir, C. Cockerham
  • Biology, Medicine
  • Evolution; international journal of organic evolution
  • 1984
  • 16,271
...
1
2
3
4
5
...