A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection

@article{Grossman2010ACO,
  title={A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection},
  author={Sharon R. Grossman and Ilya Shlyakhter and Elinor K. Karlsson and Elizabeth H Byrne and Shannon Morales and Gabriel Frieden and Elizabeth Hostetter and Elaine Angelino and Manuel Garber and Or Zuk and Eric S. Lander and Stephen F. Schaffner and Pardis C Sabeti},
  journal={Science},
  year={2010},
  volume={327},
  pages={883 - 886}
}
Pinpointing Genetic Selection The human genome contains hundreds of regions with evidence of recent positive natural selection, yet, for all but a handful of cases, the underlying advantageous mutation remains unknown. Current methods to detect the signal of selection often results in the identification of a broad genomic region containing many candidate regions that vary among individuals. By combining existing statistical methods, Grossman et al. (p. 883, published online 7 January) developed… 

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