A Component of Retinal Light Adaptation Mediated by the Thyroid Hormone Cascade

@inproceedings{Bedolla2011ACO,
  title={A Component of Retinal Light Adaptation Mediated by the Thyroid Hormone Cascade},
  author={Diana Eva Bedolla and Vincent Torre},
  booktitle={PloS one},
  year={2011}
}
Analysis with DNA-microrrays and real time PCR show that several genes involved in the thyroid hormone cascade, such as deiodinase 2 and 3 (Dio2 and Dio3) are differentially regulated by the circadian clock and by changes of the ambient light. The expression level of Dio2 in adult rats (2-3 months of age) kept continuously in darkness is modulated by the circadian clock and is up-regulated by 2 fold at midday. When the diurnal ambient light was on, the expression level of Dio2 increased by 4-8… CONTINUE READING