A Complex of BBS1 and NPHP7 Is Required for Cilia Motility in Zebrafish

Abstract

Bardet-Biedl syndrome (BBS) and nephronophthisis (NPH) are hereditary autosomal recessive disorders, encoded by two families of diverse genes. BBS and NPH display several overlapping phenotypes including cystic kidney disease, retinitis pigmentosa, liver fibrosis, situs inversus and cerebellar defects. Since most of the BBS and NPH proteins localize to… (More)
DOI: 10.1371/journal.pone.0072549

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