A Complex-based Reconstruction of the Saccharomyces cerevisiae Interactome *S⃞

@article{Wang2009ACR,
  title={A Complex-based Reconstruction of the Saccharomyces cerevisiae Interactome *S⃞},
  author={Haidong Wang and Boyko Kakaradov and Sean R. Collins and Lena Karotki and Dorothea Fiedler and Michael Shales and Kevan M. Shokat and Tobias C. Walther and Nevan J. Krogan and Daphne Koller},
  journal={Molecular & Cellular Proteomics : MCP},
  year={2009},
  volume={8},
  pages={1361 - 1381}
}
Most cellular processes are performed by proteomic units that interact with each other. These units are often stoichiometrically stable complexes comprised of several proteins. To obtain a faithful view of the protein interactome we must view it in terms of these basic units (complexes and proteins) and the interactions between them. This study makes two contributions toward this goal. First, it provides a new algorithm for reconstruction of stable complexes from a variety of heterogeneous… CONTINUE READING

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