A Complex Small RNA Repertoire Is Generated by a Plant/Fungal-Like Machinery and Effected by a Metazoan-Like Argonaute in the Single-Cell Human Parasite Toxoplasma gondii

@inproceedings{Braun2010ACS,
  title={A Complex Small RNA Repertoire Is Generated by a Plant/Fungal-Like Machinery and Effected by a Metazoan-Like Argonaute in the Single-Cell Human Parasite Toxoplasma gondii},
  author={Laurence Braun and Dominique Cannella and Philippe Ortet and Mohamed Barakat and C{\'e}line F. Sautel and Sylvie Kieffer and J{\'e}r{\^o}me Garin and Olivier Bastien and Olivier Voinnet and Mohamed-Ali Hakimi},
  booktitle={PLoS pathogens},
  year={2010}
}
In RNA silencing, small RNAs produced by the RNase-III Dicer guide Argonaute-like proteins as part of RNA-induced silencing complexes (RISC) to regulate gene expression transcriptionally or post-transcriptionally. Here, we have characterized the RNA silencing machinery and exhaustive small RNAome of Toxoplasma gondii, member of the Apicomplexa, a phylum of animal- and human-infecting parasites that cause extensive health and economic damages to human populations worldwide. Remarkably, the small… CONTINUE READING

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