A Comparison of the Physicochemical and Biological Properties of Mirtazapine and Mianserin

@article{Kelder1997ACO,
  title={A Comparison of the Physicochemical and Biological Properties of Mirtazapine and Mianserin},
  author={Jan Kelder and Carel W. Funke and Thus Boer and Leon P. C. Delbressine and Dirk D. Leysen and Victor Johannes Nickolson},
  journal={Journal of Pharmacy and Pharmacology},
  year={1997},
  volume={49}
}
Although the chemical structures of the antidepressants mirtazapine and mianserin are closely related there are considerable differences in their biological properties. To find an explanation of this, various physicochemical properties of mirtazapine and mianserin were measured or calculated. 

Antitumor activity of mianserin (a tetracyclic antidepressant) primarily driven by the inhibition of SLC1A5-mediated glutamine transport

The current findings confirmed the feasibility of targeting SLC1A5-mediated glutamine uptake as a novel approach for antitumor intervention and it is anticipated that structural insights obtained based on homology modeling would lead to the discovery of more potent and specific SLC 1A5 inhibitors for clinical development.

Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4.

Induction/inhibition or genetic polymorphisms of CYP2D6, CYP1A2, and CYP3A4 may affect MIR metabolism, but involvement of several enzymes in different metabolic pathways may prevent large alterations in in vivo drug clearance.

In vitro metabolism of mirtazapine enantiomers by human cytochrome P450 enzymes

The metabolism of mirtazapine enantiomers was investigated in vitro using human lymphoblast microsomes transfected with human cDNA to overexpress either CYP1A2, CYP2C9, CYP2C19, CYP2D6 or CYP3A4 and

Enantioseparation and molecular modeling study of eight psychoactive drugs on a coated polysaccharide‐based chiral stationary phase

Chiral separation mechanisms have been discussed in detail, and it has been confirmed that hydrogen bond, π–π, hydrophobic interactions, and some special interactions synergistically contributed to the enantioseparation of psychoactive drugs.

Enantiomeric separation of mirtazapine and its metabolites by nano-liquid chromatography with UV-absorption and mass spectrometric detection.

The nanoLC system was connected to a mass spectrometer through a nanoelectrospray interface and the MS, MS2, and MS3 spectra were acquired showing the potential of the system used for characterization and identification of the separated analytes.

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