A Comparison of the Pharmacokinetics of Oral and Sublingual Cyproheptadine

@article{Gunja2004ACO,
  title={A Comparison of the Pharmacokinetics of Oral and Sublingual Cyproheptadine},
  author={Naren Gunja and Michael Collins and Andis Graudins},
  journal={Journal of Toxicology: Clinical Toxicology},
  year={2004},
  volume={42},
  pages={79 - 83}
}
Background: Cyproheptadine is reported to be effective in treating serotonin syndrome. It is only available as an oral preparation and administration after SSRI overdose treated with activated charcoal is problematic. Sublingual administration may circumvent this problem. The pharmacokinetics of sublingual cyproheptadine are not characterized. This study compares the pharmacokinetics of cyproheptadine following oral and sublingual administration. Methods: Cross‐over, non‐blinded, volunteer… 
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