A Comparison of the Oxytocin and Vasopressin Responses to the 5-HT1A Agonist and Potential Anxiolytic Drug Alnespirone (S-20499)

  title={A Comparison of the Oxytocin and Vasopressin Responses to the 5-HT1A Agonist and Potential Anxiolytic Drug Alnespirone (S-20499)},
  author={Louis D. Kar and Andrew D. Levy and Qian Li and Mark S. Brownfield},
  journal={Pharmacology Biochemistry and Behavior},

Moderate role of oxytocin in the pro-ejaculatory effect of the 5-HT1A receptor agonist 8-OH-DPAT.

Activation of OXT neurons plays a moderate role in the pro-ejaculatory effects of systemic 8-OH-DPAT, but extracellular 5-HT levels may influence the strength of the effects.

Studies on the neuroendocrine role of serotonin.

Investigating in male Wistar rats, the involvement of serotonin (5-HT) and 5-HT receptors in the regulation of the gene expression of hypothalamic hormones and in the secretion of the pituitary gland hormones prolactin, adrenocorticotropic hormone (ACTH), vasopressin (AVP) and oxytocin in basal and stress conditions found CRH was found to have a major role but not a complete responsibility.

Oxytocin involvement in SSRI-induced delayed ejaculation: a review of animal studies.

Preliminary data suggest that the severity of chronic SSRI treatment-induced delayed ejaculation and the differences between the various SSRIs in inducing ejaculation delay is related to gradual desensitization of 5-HT(1A) receptors on oxytocin neurons.

Serotonin Receptors Involved in Vasopressin and Oxytocin Secretion

5‐HT‐induced vasopressin secretion primarily is mediated via 5‐HT2C, 4‐HT4 and 5‐ HT7 receptors, whereas 5-HT2A, 5‐ht3 and 5­HT5A receptors seem to be of minor importance.

The role of oxytocin in male and female reproductive behavior.

Brain region-specific transcriptomic markers of serotonin-1A receptor agonist action mediating sexual rejection and aggression in female marmoset monkeys.

Brain region-specific alterations of gene expression regulating neural circuitries, energy demands, and learning processes are associated with 8-OH-DPAT-induced decrease in female sexual receptivity and increase in pairmate aggression.



Effect of serotonin on vasopressin release: a comparison to corticosterone, prolactin and renin.

The data demonstrate that vasopressin levels are elevated briefly following 5-HT i.c.v., consistent with the pharmacologic profile of the early cardiovascular response.

Enhanced serotonergic transmission stimulates oxytocin secretion in conscious male rats.

Evidence is provided that enhanced serotonergic transmission stimulates oxytocin secretion and that 5-HT2 receptors contribute to this effect.

Chronic fluoxetine induces a gradual desensitization of 5-HT1A receptors: reductions in hypothalamic and midbrain Gi and G(o) proteins and in neuroendocrine responses to a 5-HT1A agonist.

The similarity in time course between fluoxetine-induced reductions in hormone responses to 8-OH-DPAT and the reduction in hypothalamic levels of Gi1 and Gi3 proteins suggests that a reduction in leptin levels ofGi3 and/or Gi1 proteins plays a role in the gradual desensitization of 5-hydroxytryptamine1A receptors induced by fluoxettine.

Neuroendocrine and cardiovascular effects of serotonin: selective role of brain angiotensin on vasopressin.

Results demonstrate that 5-HT-induced AVP secretion is mediated selectively via brain angiotensinergic mechanisms by way of the AT1 receptor.

Hypothalamic paraventricular nucleus lesions differentially affect serotonin-1A (5-HT1A) and 5-HT2 receptor agonist-induced oxytocin, prolactin, and corticosterone responses.

The present findings suggest that the PVN or neural pathways close to it mediate oxytocin, PRL, and corticosterone responses to the 5-HT2 receptor agonist DOI as well as cortic testosterone, but not PRL; but the results after long term PVN lesioning show that the oxytoc in and cortiosterone responses may be partially restored with time after lesioned.