A Comparison of Vitamin A and Leucovorin for the Prevention of Methotrexate-Induced Micronuclei Production in Rat Bone Marrow

@article{Madhyastha2008ACO,
  title={A Comparison of Vitamin A and Leucovorin for the Prevention of Methotrexate-Induced Micronuclei Production in Rat Bone Marrow},
  author={S. Madhyastha and L. Prabhu and V. Saralaya and R. Rai},
  journal={Clinics (Sao Paulo, Brazil)},
  year={2008},
  volume={63},
  pages={821 - 826}
}
  • S. Madhyastha, L. Prabhu, +1 author R. Rai
  • Published 2008
  • Medicine
  • Clinics (Sao Paulo, Brazil)
  • INTRODUCTION Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis. In rats, methotrexate is known to induce micronuclei formation, leading to genetic damage, while vitamin A is known to protect against such methotrexate-induced genetic damage. Leucovorin (folinic acid) is generally administered with methotrexate to decrease methotrexate-induced toxicity… CONTINUE READING
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