A Comparison of Vitamin A and Leucovorin for the Prevention of Methotrexate-Induced Micronuclei Production in Rat Bone Marrow

@article{Madhyastha2008ACO,
  title={A Comparison of Vitamin A and Leucovorin for the Prevention of Methotrexate-Induced Micronuclei Production in Rat Bone Marrow},
  author={Sampath Madhyastha and Latha V Prabhu and Vasudha V. Saralaya and Rajalakshmi Rai},
  journal={Clinics (Sao Paulo, Brazil)},
  year={2008},
  volume={63},
  pages={821 - 826}
}
INTRODUCTION Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis. In rats, methotrexate is known to induce micronuclei formation, leading to genetic damage, while vitamin A is known to protect against such methotrexate-induced genetic damage. Leucovorin (folinic acid) is generally administered with methotrexate to decrease methotrexate-induced toxicity… Expand
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References

SHOWING 1-10 OF 48 REFERENCES
PROTECTIVE EFFECT OF VITAMIN A ON METHOTREXATE INDUCED MICRONUCLEI
TLDR
The results of this study suggest that vitamin A protects against methotrexate induced genetic damage. Expand
Protective effect of folinic acid on low-dose methotrexate genotoxicity
TLDR
Folinic acid has a protective affect against MTX genotoxicity in human as well as in animal models and in RA patients, folinic acid provides satisfactory improvement of MTX-induced genetic damage. Expand
Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells.
TLDR
Results indicate that FA is capable of reducing the cytogenetic damage induced by MTX and appears to be an anticlastogenic agent. Expand
Mechanism of induction of micronuclei and chromosome aberrations in mouse bone marrow by multiple treatments of methotrexate.
TLDR
The multiple-dose effects of MTX on the induction of micronuclei and chromosomal aberrations may be explained by the intracellular accumulation ofMTX resulting in an enhancement of enzyme inhibition. Expand
The genotoxic and cytotoxic effects of ribavirin in rat bone marrow.
TLDR
It is suggested that ribavirin is genotoxic and cytotoxic agent for rat bone marrow by employing the micronucleus assay. Expand
Protective effects of vitamin A against the genotoxicity of NNK, a nicotine-derived N-nitrosamine.
TLDR
Results showed that hepatocytes isolated from rats fed a vitamin A supplemented diets but without NNK treatment in vivo metabolized NNK less effectively than hepatocytes isolate from rats feeding aitamin A deficient diet (group B) (NNK metabolism was decreased by 0.5-fold in group C as compared to group B). Expand
Management of cutaneous lupus erythematosus with low-dose methotrexate: indication for modulation of inflammatory mechanisms
Abstract There is no consensus about an effective and safe treatment for patients with cutaneous lupus erythematosus (LE) who are refractory to antimalarials and/or low-dose oralExpand
Adverse events in methotrexate-treated rheumatoid arthritis patients.
TLDR
The purpose of this paper is to discuss the possible mechanisms responsible for toxicity due to MTX used at low weekly pulse doses for the treatment of RA, as well as the different toxic manifestations reported in the literature. Expand
The type and time of occurrence of aminopterin-induced chromosome aberrations in cultured Potorous cells.
Abstract Many inhibitors of DNA synthesis have been found to induce chromosome aberrations. Our kinetic studies indicate that treatment of cellswith 10−7 M aminopterin in the presence of 10−4MExpand
Effectiveness of beta-carotene in cancer chemoprevention.
TLDR
A definitive evaluation of the ability of beta-carotene to prevent cancer in human requires further controlled trials; studies on a larger spectrum of cancer sites and different stages of disease must be encouraged. Expand
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