A Comparison of Personality, Life Events, Comorbidity, and Health in Monozygotic Twins Discordant for Anorexia Nervosa

@article{Thornton2017ACO,
  title={A Comparison of Personality, Life Events, Comorbidity, and Health in Monozygotic Twins Discordant for Anorexia Nervosa},
  author={Laura M. Thornton and Sara E. Trace and Kimberly A. Brownley and Monica {\AA}lgars and Suzanne E Mazzeo and Jocilyn E Bergin and Millie Maxwell and Paul Lichtenstein and Nancy L. Pedersen and Cynthia M. Bulik},
  journal={Twin Research and Human Genetics},
  year={2017},
  volume={20},
  pages={310 - 318}
}
Genetic and environmental factors contribute to the etiology of anorexia nervosa (AN). The co-twin control design is one of the most powerful methods available to evaluate environmental factors that could contribute to differences between monozygotic (MZ) twins who are discordant for AN. Using available data from a unique and rare sample of 22 Swedish female MZ pairs discordant for AN, we compared personality, life events, comorbidity, and health factors. Twins with AN had significantly higher… Expand
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References

SHOWING 1-10 OF 77 REFERENCES
Monozygotic twin pairs discordant for lifetime anorexia nervosa: An exploratory investigation
Although there is an increasing understanding of the impact of genetic factors on the development of anorexia nervosa (AN), clear identification of environmental risk factors remains unclear. UsingExpand
Shared Temperament Risk Factors for Anorexia Nervosa: A Twin Study
TLDR
The evidence overall supports the suggestion that anorexia nervosa may represent the expression of a common underlying familial liability to a temperament style that reflects a striving for perfectionism, a need for order, and a sensitivity to praise and reward. Expand
A comparison of early family life events amongst monozygotic twin women with lifetime anorexia nervosa, bulimia nervosa, or major depression.
TLDR
While some overlap among early life events was indicated, there was evidence to support some degree of nonoverlap among life events associated with Anorexia nervosa, BN, and MD. Expand
Twin studies of adult psychiatric and substance dependence disorders: are they biased by differences in the environmental experiences of monozygotic and dizygotic twins in childhood and adolescence?
TLDR
Differential environmental experiences of MZ and DZ twins in childhood and adolescence are unlikely to represent a substantial bias in twin studies of most major psychiatric and substance dependence disorders but may influence twin similarity for the initiation of substance use. Expand
Rethinking twins and environments: possible social sources for assumed genetic influences in twin research.
TLDR
Findings suggest that past twin studies could overstate the strength of genetic influences because some similarities in behavior among monozygotic compared to dizygotic twins stem from social influences. Expand
The Structure of Perfectionism: A Twin Study
TLDR
These multivariate twin modeling results support conceptualizations of perfectionism as a multidimensional construct and suggest CM is the core feature of Perfectionism with DA and PS serving as indicators of CM. Expand
Does intra‐uterine growth discordance predict differential risk for adult psychiatric disorder in a population‐based sample of monozygotic twins?
TLDR
Whether intra‐pair differences in birth weight predicts discordance for adult psychiatric disorders in 527 female monozygotic twin pairs from a population‐based twin registry is examined. Expand
Twin studies of eating disorders: a review.
TLDR
It is not possible to draw firm conclusions regarding the precise contribution of genetic and environmental factors to anorexia nervosa, but twin studies confirm that bulimia nervosa is familial and reveal significant contributions of additive genetic effects and of unique environmental factors in liability to bulimic nervosa. Expand
Twin studies and the etiology of eating disorders.
TLDR
The findings of the major twin studies of eating disorders are inconsistent and difficult to interpret, with estimates for the heritability of liability to bulimia nervosa ranging from 0% to 83%, and from0% to 70% for anorexia nervosa. Expand
Differential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins.
TLDR
Findings suggest that a portion of the genetic influence on eating pathology may become activated during puberty, similar to the 17-year-old twins' influence. Expand
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