A Comparison of Gene Expression Signatures from Breast Tumors and Breast Tissue Derived Cell Lines

@inproceedings{Ross2001ACO,
  title={A Comparison of Gene Expression Signatures from Breast Tumors and Breast Tissue Derived Cell Lines},
  author={Douglas T. Ross and Charles M. Perou},
  booktitle={Disease markers},
  year={2001}
}
Cell lines derived from human tumors have historically served as the primary experimental model system for exploration of tumor cell biology and pharmacology. Cell line studies, however, must be interpreted in the context of artifacts introduced by selection and establishment of cell lines in vitro. This complication has led to difficulty in the extrapolation of biology observed in cell lines to tumor biology in vivo. Modern genomic analysis tool like DNA microarrays and gene expression… CONTINUE READING

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References

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Showing 1-10 of 41 references

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Therese Sørliea, Charles M. Peroua, +14 authors Anne-Lise Børresen-Daleb
2001
View 5 Excerpts
Highly Influenced

Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF

H. D. Soule
Cancer Res • 1990
View 6 Excerpts
Highly Influenced

Schnitt, Pathology of the breast

S.J.F.A. Tavassoli
New York: Elsevier. xiii, • 1992
View 3 Excerpts
Highly Influenced

Establishment and characterization of a cell line of human breast carcinoma

I. Keydar
origin, Eur J Cancer • 1979
View 5 Excerpts
Highly Influenced

Isolation of two human tumor epithelial cell lines from solid breast carcinomas.

Journal of the National Cancer Institute • 1978
View 6 Excerpts
Highly Influenced

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

J. B. Welsh
Proc Natl Acad Sci USA • 2001
View 1 Excerpt

Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression

H. Okabe
Cancer Res • 2001
View 1 Excerpt

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