A Comparison of Cinnarizine and Transdermal Scopolamine for the Prevention of Seasickness in Naval Crew: A Double-Blind, Randomized, Crossover Study

  title={A Comparison of Cinnarizine and Transdermal Scopolamine for the Prevention of Seasickness in Naval Crew: A Double-Blind, Randomized, Crossover Study},
  author={A. Nieto Gil and Zohar Nachum and Dror Tal and Avi Shupak},
  journal={Clinical Neuropharmacology},
ObjectivesThe objective of the study was to compare the efficacy of transdermal scopolamine and cinnarizine in the prevention of seasickness and their adverse reactions. MethodsSeventy-six naval crew members participated in a double-blind, randomized, crossover study. On 2 voyages, they were administered either a transdermal scopolamine patch containing 1.5 mg scopolamine and placebo tablets or 25-mg cinnarizine tablets and a placebo patch. Subjects completed questionnaires for each voyage… 
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It is suggested that dimenhydrinate, 100 mg, adversely affects psychomotor function, whereas single doses of cinnarizine, 50 mg, and transdermal scopolamine appear to be free of side-effects on performance and seem to be a preferable anti-seasickness drug for use by a naval crew.
Effect of cinnarizine in the prevention of seasickness.
Cinnarizine 50 mg was found to be effective in the prevention of seasickness in rough seas and no notable side effects were found for any drug group.
Comparison of Seven Commonly Used Agents for Prophylaxis of Seasickness.
There was no significant difference in the incidence and characteristics of adverse events reported in the various medication groups, and scopolamine Transdermal Therapeutic System (TTS) users exhibited slightly more visual problems and the agent tended to be less effective.
A comparison of the efficacy of cinnarizine with scopolamine in the treatment of seasickness.
Scopolamine was shown to be more effective than cinnarizine in protecting against the symptoms of seasickness and in mild motion, cinnARizine was better tolerated than scopolamine in having less marked side effects.
Transdermally administered scopolamine vs. dimenhydrinate. I. Effect on nausea and vertigo in experimentally induced motion sickness.
Dimenhydrinate and TTS-scopolamine are both effective against motion sickness, the latter provided it is applied 6 to 8 hours before exposure to the stimulus causing the motion sickness.
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