A Comparison of Cinnarizine and Transdermal Scopolamine for the Prevention of Seasickness in Naval Crew: A Double-Blind, Randomized, Crossover Study

@article{Gil2012ACO,
  title={A Comparison of Cinnarizine and Transdermal Scopolamine for the Prevention of Seasickness in Naval Crew: A Double-Blind, Randomized, Crossover Study},
  author={A. Nieto Gil and Zohar Nachum and Dror Tal and Avi Shupak},
  journal={Clinical Neuropharmacology},
  year={2012},
  volume={35},
  pages={37–39}
}
ObjectivesThe objective of the study was to compare the efficacy of transdermal scopolamine and cinnarizine in the prevention of seasickness and their adverse reactions. MethodsSeventy-six naval crew members participated in a double-blind, randomized, crossover study. On 2 voyages, they were administered either a transdermal scopolamine patch containing 1.5 mg scopolamine and placebo tablets or 25-mg cinnarizine tablets and a placebo patch. Subjects completed questionnaires for each voyage… 
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17 Citations

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МОРСКАЯ БОЛЕЗНЬ - СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ
TLDR
The paper describes the current state of development of seasickness as one of movement disease variants, and the main directions of improving the system of measures aimed at maintaining efficiency in the presence of symptoms of Seasickness are determined.
Scuba diving and otology: a systematic review with recommendations on diagnosis, treatment and post-operative care.
TLDR
A systematic and comprehensive literature review including the pathophysiology, diagnosis, and treatment of otologic pathology related to diving, as well as facial nerve complications, mal de debarquement syndrome, sea sickness and fitness to dive recommendations following otologic surgery are performed.
The Toxicity and Attenuation Methods of Toxic Chinese Materia Medica for its Reasonable Application: A Review.
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In this review, the toxic components and their toxicological mechanisms of some toxic CMM were listed according to the chemical structure classification of toxic components.
The Neurophysiology and Treatment of Motion Sickness.
TLDR
The various types of motion sickness can be treated with general measures to lessen the intersensory conflict, behavioral changes, and drugs.
Neuronal Mechanisms and the Treatment of Motion Sickness
TLDR
An overview of the physiological basis, clinical picture and treatment options for motion sickness is provided and scopolamine and antihistamines are the most effective drugs.
Prevention and treatment of motion sickness.
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Patients should learn to identify situations that will lead to motion sickness and minimize the amount of unpleasant motion they are exposed to by avoiding difficult conditions while traveling or by positioning themselves in the most stable part of the vehicle.
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References

SHOWING 1-10 OF 15 REFERENCES
The effects of dimenhydrinate, cinnarizine and transdermal scopolamine on performance
TLDR
It is suggested that dimenhydrinate, 100 mg, adversely affects psychomotor function, whereas single doses of cinnarizine, 50 mg, and transdermal scopolamine appear to be free of side-effects on performance and seem to be a preferable anti-seasickness drug for use by a naval crew.
Effect of cinnarizine in the prevention of seasickness.
TLDR
Cinnarizine 50 mg was found to be effective in the prevention of seasickness in rough seas and no notable side effects were found for any drug group.
Comparison of Seven Commonly Used Agents for Prophylaxis of Seasickness.
TLDR
There was no significant difference in the incidence and characteristics of adverse events reported in the various medication groups, and scopolamine Transdermal Therapeutic System (TTS) users exhibited slightly more visual problems and the agent tended to be less effective.
A comparison of the efficacy of cinnarizine with scopolamine in the treatment of seasickness.
TLDR
Scopolamine was shown to be more effective than cinnarizine in protecting against the symptoms of seasickness and in mild motion, cinnARizine was better tolerated than scopolamine in having less marked side effects.
Transdermally administered scopolamine vs. dimenhydrinate. I. Effect on nausea and vertigo in experimentally induced motion sickness.
TLDR
Dimenhydrinate and TTS-scopolamine are both effective against motion sickness, the latter provided it is applied 6 to 8 hours before exposure to the stimulus causing the motion sickness.
A Double Blind Comparative Trial of Powdered Ginger Root, Hyosine Hydrobromide, and Cinnarizine in the Prophylaxis of Motion Sickness Induced by Cross Coupled Stimulation,
TLDR
The study confirmed the effectiveness of hyoscine in delaying the onset of motion sickness symptoms and showed cinnarizine to the similarly effective, however it failed to substantiate a previous report that powdered root ginger is of value in the prophylaxis ofmotion sickness.
Cinnarizine in the prophylaxis of seasickness: Laboratory vestibular evaluation and sea study
TLDR
It is concluded that 50 mg cinnarizine is an effective drug for the prevention of seasickness and the reduction in vestibular sensitivity observed even after administration of 25mg cinnarezine may explain the potency of cinnARizine in the Prevention of Seasickness.
Transdermal Scopolamine for Prevention of Motion Sickness
TLDR
TTS-S has proved to be significantly superior to placebo in reducing the incidence and severity of motion sickness by 60–80% and similar intraindividual absorption and sustained clinical efficacy with long-term use of the drug.
Postural dynamics and habituation to seasickness
Evaluation of sixteen anti-motion sickness drugs under controlled laboratory conditions.
Abstract : The effectiveness of a drug in reducing susceptibility to acute motion sickness is readily determined in a slow rotation room (SRR) where the stressful Coriolis accelerations are under…
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