A Comparison of Azacitidine and Decitabine Activities in Acute Myeloid Leukemia Cell Lines

@inproceedings{Hollenbach2010ACO,
  title={A Comparison of Azacitidine and Decitabine Activities in Acute Myeloid Leukemia Cell Lines},
  author={Paul W. Hollenbach and Aaron N. Nguyen and Helen Brady and Michelle J Williams and Yuhong Ning and Normand Richard and Leslie Krushel and Sharon Lea Aukerman and Carla Heise and Kyle J Macbeth},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The cytidine nucleoside analogs azacitidine (AZA) and decitabine (DAC) are used for the treatment of patients with myelodysplastic syndromes and acute myeloid leukemia (AML). Few non-clinical studies have directly compared the mechanisms of action of these agents in a head-to-head fashion, and the agents are often viewed as mechanistically similar DNA hypomethylating agents. To better understand the similarities and differences in mechanisms of these drugs, we compared their in vitro… CONTINUE READING
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