A Comparison of Abstract Rules in the Prefrontal Cortex, Premotor Cortex, Inferior Temporal Cortex, and Striatum

@article{Muhammad2006ACO,
  title={A Comparison of Abstract Rules in the Prefrontal Cortex, Premotor Cortex, Inferior Temporal Cortex, and Striatum},
  author={Rahmat Muhammad and Jonathan D. Wallis and Earl K. Miller},
  journal={Journal of Cognitive Neuroscience},
  year={2006},
  volume={18},
  pages={974-989}
}
The ability to use abstract rules or principles allows behavior to generalize from specific circumstances. We have previously shown that such rules are encoded in the lateral prefrontal cortex (PFC) and premotor cortex (PMC). Here, we extend these investigations to two other areas directly connected with the PFC and the PMC, the inferior temporal cortex (ITC) and the dorsal striatum (STR). Monkeys were trained to use two abstract rules: same or different. They had to either hold or release a… 
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References

SHOWING 1-10 OF 43 REFERENCES
From rule to response: neuronal processes in the premotor and prefrontal cortex.
TLDR
The ability to use abstract rules or principles allows behavior to generalize from specific circumstances and is investigated by recording from the PFC and the premotor cortex of monkeys trained to use two abstract rules.
Single neurons in prefrontal cortex encode abstract rules
The ability to abstract principles or rules from direct experience allows behaviour to extend beyond specific circumstances to general situations. For example, we learn the ‘rules’ for restaurant
A Comparison of Primate Prefrontal and Inferior Temporal Cortices during Visual Categorization
TLDR
The ITC seems more involved in the analysis of currently viewed shapes, whereas the PFC showed stronger category signals, memory effects, and a greater tendency to encode information in terms of its behavioral meaning.
Interaction of ventral and orbital prefrontal cortex with inferotemporal cortex in conditional visuomotor learning.
TLDR
The results indicate that PFv+o interacts with IT in both the learning and retention of conditional visuomotor associations, and frontotemporal interaction also appears to be important for higher order rules, such as those involved in the matching task.
Frontal Networks for Learning and Executing Arbitrary Stimulus-Response Associations
TLDR
Functional magnetic resonance imaging was performed while subjects learned by trial and error to associate sets of abstract visual stimuli with arbitrary manual responses and showed that distinct components of the dorsolateral, ventrolateral, and anterior PFC, lateral premotor cortex, supplementary motor area, and the striatum are involved in learning versus executing categorical S-R rules.
Different time courses of learning-related activity in the prefrontal cortex and striatum
TLDR
During associative learning in monkeys, neural activity in these areas changes at different rates: the striatum showed rapid, almost bistable, changes compared with a slower trend in the prefrontal cortex that was more in accordance with slow improvements in behavioural performance.
Executive frontal functions
  • J. Fuster
  • Biology, Psychology
    Experimental Brain Research
  • 2000
TLDR
This chapter presents a conceptual model of the representational and executive functions of the cortex of the frontal lobe derived from empirical evidence obtained principally in the monkey, which suggests that at least one of the mechanisms for the retention of working memory of either kind seems to be the reentry of excitability through recurrent cortical circuits.
Rule-dependent neuronal activity in the prefrontal cortex
TLDR
The hypothesis that PF plays a role in the guidance of behavior according to previously learned rules in a monkey performed a task according to two different rules, termed conditional and spatial, is supported.
Comparison of learning‐related neuronal activity in the dorsal premotor cortex and striatum
TLDR
As monkeys learned conditional visuomotor associations, neurons in the premotor cortex and associated parts of the putamen changed their rates at approximately the same time, confirming the hypothesis that cortex and basal ganglia function in distributed architectures known as cortical–basal ganglionic modules or ‘loops’.
Prefrontal cortex and caudate nucleus in conditional associative learning: dissociated effects of selective brain lesions in rats.
TLDR
The results provide further evidence that multiple brain regions participate in relatively simple behavioral tasks and that their respective contributions can be dissociated.
...
1
2
3
4
5
...