A Comparative Evaluation of Systemic Azithromycin and Ornidazole - Ofloxacin Combination as an Adjunct to Scaling and Root Planing In the Treatment of Chronic Generalised Periodontitis

@article{Boid2015ACE,
  title={A Comparative Evaluation of Systemic Azithromycin and Ornidazole - Ofloxacin Combination as an Adjunct to Scaling and Root Planing In the Treatment of Chronic Generalised Periodontitis},
  author={Apurva Boid and Sangeeta Muglikar and Rashmi Hegde},
  journal={Dentistry 3000},
  year={2015},
  volume={5},
  pages={1-4}
}
Background: It is a well-established fact that various periodontal diseases are caused by bacteria, some of which are tissue invasive. It has been suggested that an antibiotic strength 500 times greater than the usual therapeutic dose may be needed to be effective against bacteria arranged in biofilm. However, so far, the literature shows that the ideal treatment is mechanical removal of local factors followed by systemic anti-infective therapy. Aims and Objective: To evaluate and compare the… 
3 Citations
PATTERNS OF PRESCRIPTION AND USAGE OF ANTIMICROBIAL AGENTS FOR THE PROPHYLAXIS OF SURGICAL SITE INFECTIONS IN A TERTIARY CARE HOSPITAL IN KARNATAKA, SOUTH INDIA
Background: Surgical Site Infections (SSI) are considered to be the most common post-operative complication and second most common cause of nosocomial infections. The administration of empirical
A Comparative Evaluation of Systemic Azithromycin and Ornidazole - Ofloxacin Combination as an Adjunct to Scaling and Root Planing In the Treatment of Chronic Generalised Periodontitis
TLDR
Comparing the clinical effects of systemic Azithromycin and Ornidazole-Ofloxacin combination as an adjunct to Scaling and Root Planning in the treatment of patients with chronic periodontitis showed statistically significant improvement in all the three groups.

References

SHOWING 1-10 OF 30 REFERENCES
Azithromycin as an adjunct to scaling and root planing in the treatment of Porphyromonas gingivalis-associated periodontitis: a pilot study.
TLDR
Within the limitations of this study, the adjunctive use of systemic azithromycin in the treatment of P. gingivalis periodontitis demonstrated significant clinical and microbiological benefits when compared with SRP plus placebo.
Efficacy of Azithromycin in Comparison with Metronidazole in the Treatment of Chronic Periodontitis
TLDR
The adjunctive use of azithromycin with SRP has potential to improve periodontal health over SRP only and could be an interesting alternative to metronidazole from patients with chronic periodontitis.
Clinical and microbiological effects of azithromycin in the treatment of generalized chronic periodontitis: a randomized placebo-controlled clinical trial.
TLDR
The data of the present study suggest no adjunctive benefit of AZM in the treatment of generalized ChP, and both therapies equally reduced the mean probing depth and improved the mean clinical attachment.
A role for antibiotics in the treatment of refractory periodontitis.
TLDR
Preliminary analyses have indicated that at least two patterns or rates of attachment loss may be associated with refractory periodontitis and that each pattern may be indicative of a different microflora.
Benefits of additional courses of systemic azithromycin in periodontal disease case report.
TLDR
It is concluded that the single course of systemic antimicrobials currently used in periodontal therapy may be insufficient to reach necessary therapeutic levels in infected sites.
Local drug delivery of 0.5% azithromycin in the treatment of chronic periodontitis among smokers.
TLDR
The adjunctive use of 0.5% azithromycin as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis in smokers resulted in significant improvement in clinical outcome.
Clinical response of azithromycin as an adjunct to non-surgical periodontal therapy in smokers.
TLDR
The utilization of AZM in combination with SRP improves the efficacy of non-surgical periodontal therapy in reducing probing depth and improving attachment levels in smokers with moderate to advanced attachment loss.
Azithromycin in periodontal treatment: more than an antibiotic.
TLDR
Azithromycin could have a triple role in the treatment and resolution of periodontal diseases: suppressing periodontopathogens, anti-inflammatory activity and healing through persistence at low levels in macrophages and fibroblasts inperiodontal tissues, even after a single course of three tablets.
Azithromycin as an adjunctive treatment of aggressive periodontitis: 12-months randomized clinical trial.
TLDR
The adjunctive use of azithromycin has the potential to improve periodontal health of young patients with AgP.
Effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis.
TLDR
Adjunctive azithromycin therapy provides no additional benefit over nonsurgical periodontal treatment on clinical parameters, microbiological parameters and gingival crevicular fluid biochemical markers investigated in patients with generalized aggressive periodontitis.
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