A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations

@inproceedings{Thiel2017ACA,
  title={A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations},
  author={Christoph Thiel and Henrik Cordes and Lorenzo Fabbri and H{\'e}l{\`e}ne Eloise Aschmann and Vanessa Baier and Ines Smit and Francis Atkinson and Lars Mathias Blank and Lars Kuepfer},
  booktitle={PLoS Computational Biology},
  year={2017}
}
Drug-induced toxicity is a significant problem in clinical care. A key problem here is a general understanding of the molecular mechanisms accompanying the transition from desired drug effects to adverse events following administration of either therapeutic or toxic doses, in particular within a patient context. Here, a comparative toxicity analysis was performed for fifteen hepatotoxic drugs by evaluating toxic changes reflecting the transition from therapeutic drug responses to toxic… CONTINUE READING
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