A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

@article{Frayling2007ACV,
  title={A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity},
  author={T. Frayling and N. Timpson and M. Weedon and E. Zeggini and R. Freathy and C. Lindgren and J. Perry and K. Elliott and H. Lango and N. W. Rayner and B. Shields and L. Harries and J. Barrett and S. Ellard and C. Groves and B. Knight and A. Patch and A. Ness and S. Ebrahim and D. Lawlor and S. Ring and Y. Ben-Shlomo and M. Jarvelin and U. Sovio and A. Bennett and D. Melzer and L. Ferrucci and R. Loos and I. Barroso and N. Wareham and F. Karpe and K. Owen and L. Cardon and M. Walker and G. Hitman and C. Palmer and A. Doney and A. Morris and George Davey Smith and A. Hattersley and M. McCarthy},
  journal={Science},
  year={2007},
  volume={316},
  pages={889 - 894}
}
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of… Expand

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