A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

@article{Frayling2007ACV,
  title={A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity},
  author={Timothy M. Frayling and Nicholas John Timpson and Michael N. Weedon and Eleftheria Zeggini and Rachel M. Freathy and Cecilia M. Lindgren and John R. B. Perry and Katherine S. Elliott and Hana Lango and Nigel William Rayner and Beverley M. Shields and Lorna W. Harries and Jeffrey C. Barrett and Sian Ellard and Christopher J. Groves and Bridget A. Knight and Ann-Marie Patch and Andy Ness and Shah Ebrahim and Deborah A. Lawlor and Susan M. Ring and Yoav Ben-Shlomo and Marjo-Riitta Jarvelin and Ulla Sovio and Amanda Bennett and David Melzer and Luigi Ferrucci and Ruth J. F. Loos and In{\^e}s Barroso and Nicholas J. Wareham and Fredrik Karpe and Katharine R. Owen and Lon R. Cardon and Mark Walker and Graham A. Hitman and Colin Neil Alexander Palmer and Alex S. F. Doney and Andrew D. Morris and George Davey Smith and Andrew T. Hattersley and Mark I. McCarthy},
  journal={Science},
  year={2007},
  volume={316},
  pages={889 - 894}
}
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of… 

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Two groups have now shown that variation in the FTO (fat mass and obesity associated) gene is associated with both adult and childhood obesity, and a similar strong association between obesity risk and different SNPs in the same region of FTO is found.

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A cluster of variants in the first intron of FTO showed a strong and highly significant association with obesity‐related traits in three independent genome‐wide association studies, a finding that has been replicated in several other studies including adults and children of European descent.

Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population

The FTO polymorphisms showed a strong association with development of extreme phenotype of obesity and adiposity modulation in a Brazilian population and influenced BMI and body weight.

Physical activity and the association of common FTO gene variants with body mass index and obesity.

The results strongly suggest that the increased risk of obesity owing to genetic susceptibility by FTO variants can be blunted through physical activity, and emphasize the important role of physical activity in public health efforts to combat obesity, particularly in genetically susceptible individuals.

Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort

Six genetic variants of ADIPOQ, FTO and LEPR genes as obesity-risk markers and a CETP gene variant as lean mass/obesity protective marker in studied Pakistani cohort are reported.
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References

SHOWING 1-10 OF 45 REFERENCES

A Common Genetic Variant Is Associated with Adult and Childhood Obesity

A dense whole-genome scan of DNA samples from the Framingham Heart Study participants was used to identify a common genetic variant near the INSIG2 gene associated with obesity, suggesting that common genetic polymorphisms are important determinants of obesity.

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

Findings suggest that several variants of ENPP1 have a primary role in mediating insulin resistance and in the development of both obesity and T2D, suggesting that an underlying molecular mechanism is common to both conditions.

GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity

The hypothesis of the orexigenic effect of GABA in humans and of a contribution of genes involved in GABA metabolism in the modulation of food intake and in the development of morbid obesity are supported.

Significant Linkage of BMI to Chromosome 10p in the U.K. Population and Evaluation of GAD2 as a Positional Candidate

It is most likely that alternative gene(s) within the broad gene-rich region of linkage on 10p are responsible for variation in body mass and susceptibility to obesity.

Obesity in children and young people: a crisis in public health.

  • T. LobsteinL. BaurR. Uauy
  • Medicine
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2004
The present report has been written to focus attention on the issue and to urge policy-makers to consider taking action before it is too late.

Genetic and Environmental Factors in Relative Body Weight and Human Adiposity

Data from the Virginia 30,000, including twins and their parents, siblings, spouses, and children, were analyzed using a structural equation model (Stealth) and no evidence was found for a special MZ twin environment, thereby supporting the equal environment assumption.

Genetics of obesity in humans.

How far the characterization of patients has informed understanding of the physiological role of leptin and the melanocortins in the regulation of human body weight and neuroendocrine function is discussed.

On a semiparametric test to detect associations between quantitative traits and candidate genes using unrelated individuals

SPTA controls for population stratification through a set of genomic markers by first deriving a genetic background variable for each sampled individual through his/her genotypes at a series of independent markers, and then modeling the relationship between trait values, genotypic scores at the candidate marker, and genetic background variables through a semiparametric model.

Principal components analysis corrects for stratification in genome-wide association studies

This work describes a method that enables explicit detection and correction of population stratification on a genome-wide scale and uses principal components analysis to explicitly model ancestry differences between cases and controls.

Prevalence of overweight and obesity in the United States, 1999-2004.

These estimates suggest that the increases in body weight are continuing in men and in children and adolescents while they may be leveling off in women; among women, no overall increases in the prevalence of obesity were observed.