A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

  title={A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity},
  author={Timothy M. Frayling and Nicholas John Timpson and Michael N. Weedon and Eleftheria Zeggini and Rachel M. Freathy and Cecilia M. Lindgren and John R. B. Perry and Katherine S. Elliott and Hana Lango and Nigel William Rayner and Beverley M. Shields and Lorna W. Harries and Jeffrey C. Barrett and Sian Ellard and Christopher J. Groves and Bridget A. Knight and Ann-Marie Patch and Andy Ness and Shah Ebrahim and Deborah A. Lawlor and Susan M. Ring and Yoav Ben-Shlomo and Marjo-Riitta Jarvelin and Ulla Sovio and Amanda Bennett and David Melzer and Luigi Ferrucci and Ruth J. F. Loos and In{\^e}s Barroso and Nicholas J. Wareham and Fredrik Karpe and Katharine R. Owen and Lon R. Cardon and Mark Walker and Graham A. Hitman and Colin Neil Alexander Palmer and Alex S. F. Doney and Andrew D. Morris and George Davey Smith and Andrew T. Hattersley and Mark I. McCarthy},
  pages={889 - 894}
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of… 

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