A Common Genetic Variant Is Associated with Adult and Childhood Obesity

@article{Herbert2006ACG,
  title={A Common Genetic Variant Is Associated with Adult and Childhood Obesity},
  author={Alan G Herbert and Norman P. Gerry and Matthew B. McQueen and Iris M. Heid and Arne Pfeufer and Thomas Illig and Heinz-Erich Wichmann and Thomas Heinz Meitinger and David J. Hunter and Frank B. Hu and Graham A. Colditz and Anke Hinney and Johannes Hebebrand and Kerstin Koberwitz and Xiaofeng Zhu and Richard S. Cooper and Kristin G. Ardlie and Helen Lyon and Joel N. Hirschhorn and Nan M. Laird and Marc E. Lenburg and Christoph Lange and Michael F. Christman},
  journal={Science},
  year={2006},
  volume={312},
  pages={279 - 283}
}
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in… Expand

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Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
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This work attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity. Expand
[Genetic determinants of obesity. Current issues].
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Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
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Subgroup analysis of homozygous carriers of the C allele of the rs7566605 variant near the INSIG2 gene revealed that this allele significantly increased the risk for obesity in already overweight individuals. Expand
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