A Combination of α-Fetoprotein and Des-γ-Carboxy Prothrombin Is Superior in Detection of Hepatocellular Carcinoma

  title={A Combination of $\alpha$-Fetoprotein and Des-$\gamma$-Carboxy Prothrombin Is Superior in Detection of Hepatocellular Carcinoma},
  author={Judith Ertle and Dominik Heider and Marc Wichert and Benedikt Keller and Robert Kueper and Philip Hilgard and Guido Gerken and Joerg Friedrich Schlaak},
  pages={121 - 131}
Background and Aim: The incidence of hepatocellular carcinoma (HCC) is increasing in western countries. Despite its low sensitivity, the diagnosis of HCC still depends on detection of α-fetoprotein (AFP). Therefore, the aim of this study was to evaluate the combined analysis of AFP and des-γ-carboxy prothrombin (DCP) in a European cohort. Methods: We performed a single-center study (164 HCC/422 controls), in which the serum concentrations of AFP and DCP were determined. Results: AFP and DCP… 

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