A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

@article{Puigserver1998ACC,
  title={A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis},
  author={Pere Puigserver and Zhidan Wu and Cheol Won Park and Reed A. Graves and Margaret Wright and Bruce M Spiegelman},
  journal={Cell},
  year={1998},
  volume={92},
  pages={829-839}
}
Adaptive thermogenesis is an important component of energy homeostasis and a metabolic defense against obesity. We have cloned a novel transcriptional coactivator of nuclear receptors, termed PGC-1, from a brown fat cDNA library. PGC-1 mRNA expression is dramatically elevated upon cold exposure of mice in both brown fat and skeletal muscle, key thermogenic tissues. PGC-1 greatly increases the transcriptional activity of PPARgamma and the thyroid hormone receptor on the uncoupling protein (UCP-1… Expand
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