A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

  title={A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis},
  author={Pere Puigserver and Zhidan Wu and Cheol Won Park and Reed A. Graves and Margaret Wright and Bruce M Spiegelman},

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The data strengthen the previous findings that NT-PGC-1α regulates mitochondrial genes involved in thermogenesis and oxidative metabolism in brown and white adipocytes and suggest that it regulates a broad spectrum of genes to meet cellular needs for adaptive thermogenesis.

Transcriptional regulation of temperature-induced remodeling of muscle bioenergetics in goldfish.

The role for NRF-1 in regulating cold-induced mitochondrial biogenesis in goldfish, with effects mediated by PGC-1β, rather than P GC-1α, is supported.

Expression of the thermogenic nuclear hormone receptor coactivator PGC-1α is reduced in the adipose tissue of morbidly obese subjects

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Sequestration of Thermogenic Transcription Factors in the Cytoplasm during Development of Brown Adipose Tissue*

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Understanding the regulation of the UCP gene expression may facilitate the development of interventions in obesity and related disorders.

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Thyroid hormone control of thermogenesis and energy balance.

  • J. E. Silva
  • Biology, Medicine
    Thyroid : official journal of the American Thyroid Association
  • 1995
Thyrotoxicosis uniquely reduces the expression of beta 3-adrenergic receptors in brown adipose tissue, and the increased obligatory thermogenesis of this condition, via afferent neural pathways, may reduce the hypothalamic stimulation of brown fat, providing additional mechanisms to limit brown fat thermogenesis in hyperthyroidism.