A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway

  title={A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway},
  author={Min Lu and Jaroslav Zak and Jian Yang and Luis S{\'a}nchez-Pulido and D T Severson and Jane A Endicott and Chris P. Ponting and Christopher J. Schofield and Xin Yuan Lu},
Regulation of nuclear import is fundamental to eukaryotic biology. The majority of nuclear import pathways are mediated by importin-cargo interactions. Yet not all nuclear proteins interact with importins, necessitating the identification of a general importin-independent nuclear import pathway. Here, we identify a code that determines importin-independent nuclear import of ankyrin repeats (ARs), a structural motif found in over 250 human proteins with diverse functions. AR-containing proteins… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS
18 Citations
49 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 18 extracted citations


Publications referenced by this paper.
Showing 1-10 of 49 references

Molecular mechanism of the nuclear protein import cycle

  • M. Stewart
  • Nat. Rev. Mol. Cell Biol
  • 2007
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…