A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway

@article{Lu2014ACF,
  title={A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway},
  author={Min Lu and Jaroslav Zak and Jian Yang and Luis S{\'a}nchez-Pulido and D T Severson and Jane A Endicott and Chris P. Ponting and Christopher J. Schofield and Xin Yuan Lu},
  journal={Cell},
  year={2014},
  volume={157},
  pages={1130-1145}
}
Regulation of nuclear import is fundamental to eukaryotic biology. The majority of nuclear import pathways are mediated by importin-cargo interactions. Yet not all nuclear proteins interact with importins, necessitating the identification of a general importin-independent nuclear import pathway. Here, we identify a code that determines importin-independent nuclear import of ankyrin repeats (ARs), a structural motif found in over 250 human proteins with diverse functions. AR-containing proteins… CONTINUE READING
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Molecular mechanism of the nuclear protein import cycle

  • M. Stewart
  • Nat. Rev. Mol. Cell Biol
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