A Coat Protein on Phagosomes Involved in the Intracellular Survival of Mycobacteria

@article{Ferrari1999ACP,
  title={A Coat Protein on Phagosomes Involved in the Intracellular Survival of Mycobacteria},
  author={G. Ferrari and H. Hans Langen and Makoto Naito and Jean Pieters},
  journal={Cell},
  year={1999},
  volume={97},
  pages={435-447}
}
Mycobacteria are intracellular pathogens that can survive within macrophage phagosomes, thereby evading host defense strategies by largely unknown mechanisms. We have identified a WD repeat host protein that was recruited to and actively retained on phagosomes by living, but not dead, mycobacteria. This protein, termed TACO, represents a component of the phagosome coat that is normally released prior to phagosome fusion with or maturation into lysosomes. In macrophages lacking TACO… CONTINUE READING
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