A Coat Protein on Phagosomes Involved in the Intracellular Survival of Mycobacteria

  title={A Coat Protein on Phagosomes Involved in the Intracellular Survival of Mycobacteria},
  author={G. Ferrari and H. Hans Langen and Makoto Naito and Jean Pieters},
Mycobacteria are intracellular pathogens that can survive within macrophage phagosomes, thereby evading host defense strategies by largely unknown mechanisms. We have identified a WD repeat host protein that was recruited to and actively retained on phagosomes by living, but not dead, mycobacteria. This protein, termed TACO, represents a component of the phagosome coat that is normally released prior to phagosome fusion with or maturation into lysosomes. In macrophages lacking TACO… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 181 extracted citations

Mycobacterium and the coat of many lipids

The Journal of cell biology • 2002
View 5 Excerpts
Highly Influenced

Tuberculosis and host metabolism: ancient associations, fresh insights.

Translational research : the journal of laboratory and clinical medicine • 2009
View 4 Excerpts
Highly Influenced

Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society • 2007
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 65 references

Mycobacterium and Leishmania: stowaways in the endosomal network.

Trends in cell biology • 1995
View 6 Excerpts
Highly Influenced

Kupffer cells and their function

E. J. 195–202. Neer, C. J. Schmidt, R. Nambudripad, T. F. Smith
Liver 7, • 1994
View 8 Excerpts
Highly Influenced

Differfied peptide recovery

L. P. Barker, K. M. George, S. Falkow, P. L. Small
Anal. Biochem. 250, 153–156. • 1997
View 4 Excerpts
Highly Influenced

Isolation and characterization of the intracellular MHC isch, G

A. Tulp, D. Verwoerd, +7 authors J. Ger-
(1995). Coronin involved in phagocytosis: dynamics of parti- class II compartment. Nature 369, 120–126. cle-induced relocalization visualized by a green fluorescent protein Valerius, N.H., Stendahl, O., Hartwig, J.H., and Stossel, T.P. (1981). tag. Cell 83, 915–924. • 1994
View 3 Excerpts
Highly Influenced

studies of a pathogenic mycobacterium and a nonpathogenic yeast

A. Blocker, G. Griffiths, J. C. Olivo, A. A. Hyman, F. F. Severin
duces phagosome-endosome fusion, • 1998
View 2 Excerpts

Cytosolic phox

A. Grogan, E. Reeves, +5 authors A. W. Segal
View 1 Excerpt

Similar Papers

Loading similar papers…