A Cluster of Cholinergic Premotor Interneurons Modulates Mouse Locomotor Activity

@article{Zagoraiou2009ACO,
  title={A Cluster of Cholinergic Premotor Interneurons Modulates Mouse Locomotor Activity},
  author={Laskaro Zagoraiou and Turgay Akay and James F. Martin and Robert M. Brownstone and Thomas M. Jessell and Gareth Miles},
  journal={Neuron},
  year={2009},
  volume={64},
  pages={645-662}
}
Mammalian motor programs are controlled by networks of spinal interneurons that set the rhythm and intensity of motor neuron firing. Motor neurons have long been known to receive prominent "C bouton" cholinergic inputs from spinal interneurons, but the source and function of these synaptic inputs have remained obscure. We show here that the transcription factor Pitx2 marks a small cluster of spinal cholinergic interneurons, V0(C) neurons, that represents the sole source of C bouton inputs to… CONTINUE READING

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Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2007
VIEW 13 EXCERPTS