A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence

@inproceedings{Chu2016ACD,
  title={A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence},
  author={Michele C Chu and Michael J G Mallozzi and Bryan P Roxas and Lisa Bertolo and Mario A. Monteiro and Al B. Agellon and V. K. Viswanathan and Gayatri Vedantam},
  booktitle={PLoS pathogens},
  year={2016}
}
Clostridium difficile is a diarrheagenic pathogen associated with significant mortality and morbidity. While its glucosylating toxins are primary virulence determinants, there is increasing appreciation of important roles for non-toxin factors in C. difficile pathogenesis. Cell wall glycopolymers (CWGs) influence the virulence of various pathogens. Five C. difficile CWGs, including PSII, have been structurally characterized, but their biosynthesis and significance in C. difficile infection is… CONTINUE READING
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