A Cloned Gene for Human Transferrin

@article{Hershberger1991ACG,
  title={A Cloned Gene for Human Transferrin},
  author={Charles Lee Hershberger and Jane Larson and Bert Arnold and Paul Rosteck and P. Williams and Bradley S. Dehoff and Paul H. Dunn and K. L. O’Neal and Mark W. Riemen and P. A. Tice and Robert Crofts and Josip Ivan{\vc}i{\'c}},
  journal={Annals of the New York Academy of Sciences},
  year={1991},
  volume={646}
}
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The ferric iron bound to the C-site of TfBSHAW is unstable in the presence of protons or 6 M urea, and the amino acid substitution is thought to be isoleucine replaced by asparagine at either position 378 or position 381. Expand
Characterization of the synergistic effect of insulin and transferrin and the regulation of their receptors on a human colon carcinoma cell line
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It appears that transferrin plays a role in regulating the insulin receptor and that this may contribute to the synergistic effect of insulin and transferrin on growth. Expand
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The results suggest that growth of human cells in bovine serum could give rise to a cellular iron deficiency, which may in turn lead to the selection of clones of cells adapted for survival with less iron, which has important consequences for the use of such cells as models. Expand
Expression of the amino-terminal half-molecule of human serum transferrin in cultured cells and characterization of the recombinant protein.
TLDR
A DNA fragment coding for the natural signal sequence, the hTF/2N lobe, and the two stop codons was cloned into the expression vector pNUT, such that the expression of hTF-2N was controlled by the mouse metallothionein promoter and the human growth hormone termination sequences. Expand
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TLDR
The cytoplasmic domain of the transferrin receptor contains a specific signal sequence located within amino acid residues 19-28 that determines high efficiency endocytosis and Tyr 20 is an important element of that sequence. Expand
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Results suggest that the acquisition of TF-bound iron by H. influenzae type b probably involves a direct interaction with an outer-membrane protein which shows some TF-species specificity. Expand
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  • Biology, Medicine
  • Comparative biochemistry and physiology. B, Comparative biochemistry
  • 1989
TLDR
The results are discussed in relation to the possible role of disulphide bridges in maintaining the shape and flexibility of the three transferrins, and in their appearance during the evolution of the transferrin family. Expand
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A strategy for synthesizing single-stranded DNA by the polymerase chain reaction method is explored and two protocols are developed that allow rapid genetic screening and population genetic analysis of sequence variation. Expand
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