A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function
@article{DeBruyne2006ACS, title={A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function}, author={Jason P. DeBruyne and Elizabeth Noton and Christopher M. Lambert and Elizabeth S. Maywood and David R. Weaver and Steven M. Reppert}, journal={Neuron}, year={2006}, volume={50}, pages={465-477} }
414 Citations
CLOCK stabilizes CYCLE to initiate clock function in Drosophila
- BiologyProceedings of the National Academy of Sciences
- 2017
The genetic architecture and molecular mechanisms required for clock initiation that are likely conserved in other eukaryotes are defined and suggested and it is suggested that ectopic clocks can be generated by Clock, cycle, and cryptochrome expression in naive cells.
Molecular components of the mammalian circadian clock.
- BiologyHuman molecular genetics
- 2006
The general mechanisms of the circadian clockwork are reviewed, recent findings that elucidate tissue-specific expression patterns of the clock genes are described and the importance of circadian regulation in peripheral tissues for an organism's overall well-being is addressed.
Divergent Roles of Clock Genes in Retinal and Suprachiasmatic Nucleus Circadian Oscillators
- BiologyPloS one
- 2012
The retinal neural clock has a unique pattern of clock gene dependence at the tissue level that it is similar in pattern, but more severe in degree, than the SCN neural clock, with divergent clock gene regulation of rhythmic period.
The Acetyltransferase CLOCK Is Dispensable for Circadian Aftereffects in Mice
- Biology, PsychologyJournal of biological rhythms
- 2011
The authors exposed Clock knockout mice to 25-hour light cycles and report that these mice retain the ability to display circadian aftereffects, indicating that Clock is dispensable for this form of circadian plasticity.
THE CROSSTALK BETWEEN PHYSIOLOGY AND CIRCADIAN CLOCK PROTEINS
- BiologyChronobiology international
- 2009
This review summarizes recent advances in the understanding of the roles of peripheral clocks and of post-translational modifications occurring on clock proteins at the intersection of physiology, metabolism, and the circadian system.
Stoichiometric Relationship among Clock Proteins Determines Robustness of Circadian Rhythms*
- BiologyThe Journal of Biological Chemistry
- 2011
These findings may explain why certain mutant mice or cells are arrhythmic, whereas others are rhythmic, and suggest that robustness of circadian rhythms can be increased even in wild-type cells by modulating the stoichiometry.
System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock
- BiologyPLoS biology
- 2007
The finding that rhythmic mPer2 expression can be driven by both systemic cues and local oscillators suggests a plausible mechanism for the phase entrainment of subsidiary clocks in peripheral organs.
Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals
- BiologyChronobiology international
- 2007
The recent advances in the knowledge of the molecular clockwork in mammals are described, in particular, the contribution of new clock components and of post‐transcriptional and post-translational events to circadian timekeeping are discussed.
A model of the cell-autonomous mammalian circadian clock
- BiologyProceedings of the National Academy of Sciences
- 2009
A mathematical model is built from the regulatory structure of the intracellular circadian clock in mice and its parameters are identified using an iterative evolutionary strategy, with minimum cost achieved through conformance to phase separations seen in cell-autonomous oscillators.
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