A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function

@article{DeBruyne2006ACS,
  title={A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function},
  author={Jason P. DeBruyne and Elizabeth Noton and Christopher M. Lambert and Elizabeth S. Maywood and David R. Weaver and Steven M. Reppert},
  journal={Neuron},
  year={2006},
  volume={50},
  pages={465-477}
}
View on Elsevier
cell.com
414 Citations
Highly Influential Citations
35
Background Citations
198
Methods Citations
28
Results Citations
15

Figures from this paper

414 Citations

Citation Type

Citation Type

Peripheral circadian oscillators require CLOCK
CLOCK stabilizes CYCLE to initiate clock function in Drosophila
TLDR
The genetic architecture and molecular mechanisms required for clock initiation that are likely conserved in other eukaryotes are defined and suggested and it is suggested that ectopic clocks can be generated by Clock, cycle, and cryptochrome expression in naive cells.
Molecular components of the mammalian circadian clock.
TLDR
The general mechanisms of the circadian clockwork are reviewed, recent findings that elucidate tissue-specific expression patterns of the clock genes are described and the importance of circadian regulation in peripheral tissues for an organism's overall well-being is addressed.
Divergent Roles of Clock Genes in Retinal and Suprachiasmatic Nucleus Circadian Oscillators
TLDR
The retinal neural clock has a unique pattern of clock gene dependence at the tissue level that it is similar in pattern, but more severe in degree, than the SCN neural clock, with divergent clock gene regulation of rhythmic period.
The Acetyltransferase CLOCK Is Dispensable for Circadian Aftereffects in Mice
TLDR
The authors exposed Clock knockout mice to 25-hour light cycles and report that these mice retain the ability to display circadian aftereffects, indicating that Clock is dispensable for this form of circadian plasticity.
THE CROSSTALK BETWEEN PHYSIOLOGY AND CIRCADIAN CLOCK PROTEINS
TLDR
This review summarizes recent advances in the understanding of the roles of peripheral clocks and of post-translational modifications occurring on clock proteins at the intersection of physiology, metabolism, and the circadian system.
Stoichiometric Relationship among Clock Proteins Determines Robustness of Circadian Rhythms*
TLDR
These findings may explain why certain mutant mice or cells are arrhythmic, whereas others are rhythmic, and suggest that robustness of circadian rhythms can be increased even in wild-type cells by modulating the stoichiometry.
System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock
TLDR
The finding that rhythmic mPer2 expression can be driven by both systemic cues and local oscillators suggests a plausible mechanism for the phase entrainment of subsidiary clocks in peripheral organs.
Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals
TLDR
The recent advances in the knowledge of the molecular clockwork in mammals are described, in particular, the contribution of new clock components and of post‐transcriptional and post-translational events to circadian timekeeping are discussed.
A model of the cell-autonomous mammalian circadian clock
TLDR
A mathematical model is built from the regulatory structure of the intracellular circadian clock in mice and its parameters are identified using an iterative evolutionary strategy, with minimum cost achieved through conformance to phase separations seen in cell-autonomous oscillators.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 62 REFERENCES
Role of the CLOCK protein in the mammalian circadian mechanism.
TLDR
CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity.
A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock
Interacting molecular loops in the mammalian circadian clock.
TLDR
Analysis of Clock/Clock mutant mice, homozygous Period2(Brdm1) mutants, and Cryptochrome-deficient mice reveals substantially altered Bmal1 rhythms, consistent with a dominant role of PERIOD2 in the positive regulation of the Bmal 1 loop.
A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock
CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP.
TLDR
Evidence is presented that circadian Dbp transcription requires the basic helix-loop-helix-PAS protein CLOCK, an essential component of the negative-feedback circuitry generating circadian oscillations in mammals and fruit flies.
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
TLDR
It is shown that transcriptional regulation of the core clock mechanism in mouse liver is accompanied by rhythms in H3 histone acetylation, and that H3 acetylations is a potential target of the inhibitory action of Cry.
Posttranslational Mechanisms Regulate the Mammalian Circadian Clock
Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals
Analysis of Clock Proteins in Mouse SCN Demonstrates Phylogenetic Divergence of the Circadian Clockwork and Resetting Mechanisms
BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system.
TLDR
Results provide evidence for an additional level of circadian system control, which is based on regulation of transcriptional activity or/and availability of CLOCK/BMAL1 complex, and all posttranslational events described in this study are coupled with active transactivation complex formation, which argues for their significant functional role.
...
1
2
3
4
5
...