A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function

@article{DeBruyne2006ACS,
  title={A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function},
  author={Jason P DeBruyne and E. Noton and C. M. Lambert and E. Maywood and D. Weaver and S. Reppert},
  journal={Neuron},
  year={2006},
  volume={50},
  pages={465-477}
}
  • Jason P DeBruyne, E. Noton, +3 authors S. Reppert
  • Published 2006
  • Medicine, Biology
  • Neuron
  • The circadian clock mechanism in the mouse is composed of interlocking transcriptional feedback loops. Two transcription factors, CLOCK and BMAL1, are believed to be essential components of the circadian clock. We have used the Cre-LoxP system to generate whole-animal knockouts of CLOCK and evaluated the resultant circadian phenotypes. Surprisingly, CLOCK-deficient mice continue to express robust circadian rhythms in locomotor activity, although they do have altered responses to light. At the… CONTINUE READING

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