A Clinically Relevant Unilateral Rat Model of Parkinsonian Akinesia

@article{Schallert1992ACR,
  title={A Clinically Relevant Unilateral Rat Model of Parkinsonian Akinesia},
  author={Timothy J Schallert and David Norton and Theresa A. Jones},
  journal={Journal of Neural Transplantation & Plasticity},
  year={1992},
  volume={3},
  pages={332 - 333}
}
In transplantation research on Parkinson’s disease, behavioral evidence of graft-specific improved function is as necessary as anatomical or chemical data in evaluating the success of the procedure. The circling model of Ungerstedt has been widely adopted to provide such evidence, in part because it is so convenient and (relative to primate models) inexpensive. In this model 6hydroxydopamine (6-OHDA) is used to deplete nigrostriatal dopamine (DA) unilaterally. A reduction of the contraversive… CONTINUE READING