A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

@article{Sharma2010ACR,
  title={A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations},
  author={Sreenath V. Sharma and Diana Yu-Lin Lee and Bihua Li and Margaret P. Quinlan and Fumiyuki Takahashi and Shanmuga S Maheswaran and Ultan McDermott and Nancy Azizian and L. Q. Zou and Michael A. Fischbach and Kwok-kin Wong and Kathleyn A. Brandstetter and Ben S. Wittner and Sridhar Ramaswamy and Marie K. Classon and Jeff Settleman},
  journal={Cell},
  year={2010},
  volume={141},
  pages={69-80}
}
Accumulating evidence implicates heterogeneity within cancer cell populations in the response to stressful exposures, including drug treatments. While modeling the acute response to various anticancer agents in drug-sensitive human tumor cell lines, we consistently detected a small subpopulation of reversibly "drug-tolerant" cells. These cells demonstrate >100-fold reduced drug sensitivity and maintain viability via engagement of IGF-1 receptor signaling and an altered chromatin state that… CONTINUE READING
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