A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety

@article{Bao2011ACH,
  title={A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety},
  author={Jun Bao and Sheng-Ming Dai},
  journal={Rheumatology International},
  year={2011},
  volume={31},
  pages={1123-1129}
}
  • Jun Bao, S. Dai
  • Published 2 March 2011
  • Medicine
  • Rheumatology International
Tripterygium wilfordii Hook F (TwHF) is a Chinese herb with immunosuppressive effects and an established history of use in the treatment of rheumatoid arthritis (RA). Numerous preclinical studies have demonstrated that the extracts from the root of TwHF inhibit the expression of proinflammatory cytokines, proinflammatory mediators, adhesion molecules, and matrix metalloproteinases by macrophages, lymphocytes, synovial fibroblasts, and chondrocytes. TwHF also induces apoptosis in lymphocytes and… Expand
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A systematic analysis on a potential anti-inflammatory and immunosuppressant herb Tripterygium wilfordii for the management of rheumatoid arthritis
Rheumatoid arthritis (RA) is the systemic autoimmune and inflammatory disease. It is marked with swollen and tender joints, redness, pain and loss of physical functions. This mostly effects women… Expand
A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis
TLDR
Current evidence shows that TWPs are more effective than other western or Chinese medicines the authors included in this meta-analysis for RA treatment with relatively lower toxicity. Expand
Tripterygium wilfordii Hook F versus conventional synthetic disease-modifying anti-rheumatic drugs as monotherapy for rheumatoid arthritis: a systematic review and network meta-analysis
TLDR
The data suggest that TwHF is effective and safe in the treatment of RA and has better clinical efficacy in terms of ACR 20 and 50 than existing conventional synthetic DMARDs. Expand
Efficacy and Safety of Tripterygium Wilfordii Hook. F for Connective Tissue Disease-Associated Interstitial Lung Disease:A Systematic Review and Meta-Analysis
TLDR
The performed meta-analysis indicated that TwHF combined with conventional treatment was more beneficial to patients for improving symptoms, lung function and laboratory indicators. Expand
Efficacy and Safety of Tripterygium Wilfordii Hook F on Psoriasis Vulgaris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
TLDR
Despite several mild side effects of TwHF, there is evidence that TwHF is an effective therapy for psoriasis, however, the conclusions are limited by the small number of included trials. Expand
A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis.
TLDR
The results show that the two herbs modulate the angiogenesis mediators through both direct and indirect pathways, and 21 common targets shared by Semen Strychni and TwHF bear major responsibility for treating RA. Expand
Evaluation of the efficacy and safety of different Tripterygium preparations on collagen-induced arthritis in rats.
TLDR
It is suggested that four TPs showed significantly therapeutic effect on ameliorating inflammation of CIA rats, with no obvious hepatotoxicity and nephrotoxicity in vivo. Expand
Therapeutic effects of total coumarins from Urtica dentata Hand on collagen-induced arthritis in Balb/c mice.
TLDR
The data suggest that total coumarins isolated from UDH provides substantial therapeutic protection against CIA by eliciting immune tolerance and it would be a valuable candidate for further investigation as a new anti-arthritic agent. Expand
Advances in Chinese Herbal Medicine for Rheumatoid Arthritis: Clinical Utilization and Efficacy, Mechanism of Action, and Safety
TLDR
It is of great significance for clinicians, researchers, and pharmaceutical companies to share responsibility by regulating the clinical use ofCHMs, strengthening the basic toxicology research, and establishing a strict quality control system to ensure the safe use of CHMs and decrease the number of toxic cases. Expand
Tripterygium wilfordii: An inspiring resource for rheumatoid arthritis treatment
TLDR
A global view of TwHF is offered, ranging from its chemical constituents, quality control, clinical observations, and underlying pharmacological mechanisms to toxic manifestations and mechanisms, which focuses on the important and emerging aspects of this field. Expand
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References

SHOWING 1-10 OF 79 REFERENCES
Comparison of Tripterygium wilfordii Hook F Versus Sulfasalazine in the Treatment of Rheumatoid Arthritis
TLDR
This trial compared TwHF extract with sulfasalazine in 121 patients with active rheumatoid arthritis who could continue oral prednisone and nonsteroidal anti-inflammatory drugs but not disease-modifying antirheumatic drugs. Expand
The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F.
TLDR
Studies on the relationship of the chemical components of TwHF and its immunosuppressive and anti-inflammatory effects suggest that diterpenoid compounds with epoxide groups account for the therapeutic effects of this herbal remedy. Expand
Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts
TLDR
The mechanism of action remains to be studied; however, triptolide may possibly have a disease-modifying effect in patients with RA. Expand
Triptolide, A Novel Immunosuppressive and Anti-Inflammatory Agent Purified from a Chinese Herb Tripterygium Wilfordii Hook F
TLDR
Current available data suggest that triptolide is a promising immunosuppressive and anti-inflammatory agent and should be explored further in autoimmune diseases and transplantation. Expand
Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts
TLDR
Triptolide decreased viability, inhibited proliferation, and induced apoptosis of RSF in a concentration-dependent manner at very low (nM) concentrations, suggesting triptolide may possibly have a disease-modifying effect in patients with RA. Expand
Effect of an extract of the Chinese herbal remedy Tripterygium wilfordii Hook F on human immune responsiveness.
TLDR
The conclusion that T2 exerts a powerful suppressive effect on human immune responses is supported, which might account for its therapeutic effectiveness in RA. Expand
A potential new treatment for rheumatoid arthritis: thunder god vine.
TLDR
Various extracts of the vinelike plant Tripterygium wilfordii Hook f have been widely used in China to treat patients with a number of autoimmune diseases and the current status of knowledge of the potential clinical benefit and possible mechanisms accounting for its utility are considered. Expand
Suppressive effects of Tripterygium wilfordii Hook f., a traditional Chinese medicine, on collagen arthritis in mice.
TLDR
A 14-day course of TWH extract treatment at a daily dose of 400 microg kg(-1), which began on the day of the first C II immunization, suppressed the development of arthritis, as well as antibody production and delayed-type hypersensitivity to C II. Expand
RADIX Tripterygium Wilfordii—A CHINESE HERBAL MEDICINE WITH POTENT IMMUNOSUPPRESSIVE PROPERTIES
TLDR
It is demonstrated that Radix Tripterygium wilfordii Hook-F is capable of inhibiting several afferent immune functions including the in vitro response of human peripheral blood mononuclear cells to both mitogen and alloantigen, and the generation of cytotoxic T cells. Expand
A phase I study of ethyl acetate extract of the chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritis.
TLDR
The EA extract of TWHF at dosages up to 570 mg/day appeared to be safe, and doses > 360 mg/ day were associated with clinical benefit in patients with RA. Expand
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