A Chimeric Study of the Molecular Basis of Affinity and Selectivity of the κ and the δ Opioid Receptors. POTENTIAL ROLE OF EXTRACELLULAR DOMAINS

@inproceedings{Meng1995ACS,
  title={A Chimeric Study of the Molecular Basis of Affinity and Selectivity of the κ and the δ Opioid Receptors. POTENTIAL ROLE OF EXTRACELLULAR DOMAINS},
  author={Fan Meng and Mary T. Hoversten and Robert Charles Thompson and Lawrence A. Taylor and Stanley J. Watson and Huda Akil},
  year={1995}
}
Abstract Within the large family of G-protein-coupled receptors, a picture is emerging which contrasts the binding of small ligands and the binding of peptides to the seven-helix configuration of the proteins. Because of its unique richness in both peptide and non-peptide ligands, the opioid receptor family offers several advantages for achieving a better understanding of similarities and differences in ligand/receptor interactions across different classes of agonists and antagonists. Since… CONTINUE READING

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Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor.

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  • 2002
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