A Chemical Approach for the Detection of Protein Sulfinylation.

  title={A Chemical Approach for the Detection of Protein Sulfinylation.},
  author={Mauro Lo Conte and Jiusheng Lin and Mark A. Wilson and Kate S. Carroll},
  journal={ACS chemical biology},
  volume={10 8},
Protein sulfinic acids are formed by the reaction of reactive oxygen species with protein thiols. Sulfinic acid formation has long been considered an irreversible state of oxidation and is associated with high cellular oxidative stress. Increasing evidence, however, indicates that cysteine is oxidized to sulfinic acid in cells to a greater extent, and is more controlled, than first thought. The discovery of sulfiredoxin has demonstrated that cysteine sulfinic acid can be reversed, pointing to a… CONTINUE READING
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