A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

  title={A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins},
  author={Joseph L Goldstein and Michael Scott Brown},
One-fourth of all deaths in industrialized countries result from coronary heart disease. A century of research has revealed the essential causative agent: cholesterol-carrying low-density lipoprotein (LDL). LDL is controlled by specific receptors (LDLRs) in liver that remove it from blood. Mutations that eliminate LDLRs raise LDL and cause heart attacks in childhood, whereas mutations that raise LDLRs reduce LDL and diminish heart attacks. If we are to eliminate coronary disease, lowering LDL… CONTINUE READING
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