A Central Role for the ERK-Signaling Pathway in Controlling Schwann Cell Plasticity and Peripheral Nerve Regeneration In Vivo

@article{Napoli2012ACR,
  title={A Central Role for the ERK-Signaling Pathway in Controlling Schwann Cell Plasticity and Peripheral Nerve Regeneration In Vivo},
  author={Ilaria E. De Napoli and Luke A. Noon and Sara Soares Ribeiro and Ajay P. Kerai and Simona Parrinello and Laura H. Rosenberg and Melissa J. Collins and Marie C. Harrisingh and Ian J. White and Ashwin Woodhoo and Alison C. Lloyd},
  journal={Neuron},
  year={2012},
  volume={73},
  pages={729-742}
}
Following damage to peripheral nerves, a remarkable process of clearance and regeneration takes place. Axons downstream of the injury degenerate, while the nerve is remodeled to direct axonal regrowth. Schwann cells are important for this regenerative process. "Sensing" damaged axons, they dedifferentiate to a progenitor-like state, in which they aid nerve regeneration. Here, we demonstrate that activation of an inducible Raf-kinase transgene in myelinated Schwann cells is sufficient to control… CONTINUE READING
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