• DOI:10.1126/scitranslmed.3001118
Corpus ID: 423446

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

@article{Larsen2010ACR,
  title={A Central Role for Free Heme in the Pathogenesis of Severe Sepsis},
  author={R. Larsen and Raffaella Gozzelino and Vikt{\'o}ria Jeney and L{\'a}szl{\'o} Tokaji and F. Bozza and A. Japiass{\'u} and Dolores Bonaparte and M. C. Cavalcante and {\^A}. Chora and A. Ferreira and I. Marguti and S{\'i}lvia Cardoso and N. Sep{\'u}lveda and Ann Smith and M. Soares},
  journal={Science Translational Medicine},
  year={2010},
  volume={2},
  pages={51ra71 - 51ra71}
}

• R. Larsen, Raffaella Gozzelino, +12 authors M. Soares
• Published 2010
• Biology, Medicine
• Science Translational Medicine

Heme from red blood cells released in septic shock worsens organ dysfunction and increases the risk of death, but can be overcome by a scavenger of free heme. Casting Heme in a New Light Sepsis, or severe systemic infection, is a deadly disease that has always been difficult to treat. Despite modern-day antibiotics and intensive care management, patients with sepsis still have a high rate of major complications and death. These severe consequences are thought to be a result of simultaneous… Expand

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