A Central Role for Free Heme in the Pathogenesis of Severe Sepsis
@article{Larsen2010ACR, title={A Central Role for Free Heme in the Pathogenesis of Severe Sepsis}, author={R. Larsen and Raffaella Gozzelino and Vikt{\'o}ria Jeney and L{\'a}szl{\'o} Tokaji and F. Bozza and A. Japiass{\'u} and Dolores Bonaparte and M. C. Cavalcante and {\^A}. Chora and A. Ferreira and I. Marguti and S{\'i}lvia Cardoso and N. Sep{\'u}lveda and Ann Smith and M. Soares}, journal={Science Translational Medicine}, year={2010}, volume={2}, pages={51ra71 - 51ra71} }
Heme from red blood cells released in septic shock worsens organ dysfunction and increases the risk of death, but can be overcome by a scavenger of free heme. Casting Heme in a New Light Sepsis, or severe systemic infection, is a deadly disease that has always been difficult to treat. Despite modern-day antibiotics and intensive care management, patients with sepsis still have a high rate of major complications and death. These severe consequences are thought to be a result of simultaneous… Expand
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