A Cellular Repressor of E1A-Stimulated Genes That Inhibits Activation by E2F

@article{Veal1998ACR,
  title={A Cellular Repressor of E1A-Stimulated Genes That Inhibits Activation by E2F},
  author={E. Veal and M. Eisenstein and Zian H. Tseng and G. Gill},
  journal={Molecular and Cellular Biology},
  year={1998},
  volume={18},
  pages={5032 - 5041}
}
ABSTRACT The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. Here we report the identification and characterization of a cellular protein that antagonizes transcriptional activation and cellular transformation by E1A. This protein, termed CREG for cellular repressor of E1A-stimulated genes, shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb… Expand
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