A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

@article{Hutvagner2001ACF,
  title={A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA},
  author={Gyorgy Hutvagner and Juanita Mclachlan and Amy E Pasquinelli and Eva Balint and Thomas Tuschl and Phillip D. Zamore},
  journal={Science},
  year={2001},
  volume={293},
  pages={834 - 838}
}
The 21-nucleotide small temporal RNA (stRNA) let-7regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in vitro evidence that in Drosophila melanogaster a developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let-7 stRNA. Targeted destruction in cultured human cells of the messenger RNA encoding the enzyme Dicer, which acts in the RNA interference pathway, leads to… 
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