A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells

@inproceedings{Ware2018ACC,
  title={A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells},
  author={Brenton R. Ware and Mitchell J. Durham and Chase P. Monckton and Salman R Khetani},
  booktitle={Cellular and molecular gastroenterology and hepatology},
  year={2018}
}
Background and Aims Modeling interactions between primary human hepatocytes (PHHs) and primary human liver sinusoidal endothelial cells (LSECs) in vitro can help elucidate human-specific mechanisms underlying liver physiology/disease and drug responses; however, existing hepatocyte/endothelial coculture models are suboptimal because of their use of rodent cells, cancerous cell lines, and/or nonliver endothelial cells. Hence, we sought to develop a platform that could maintain the long-term… CONTINUE READING
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