A Cell-Based Systems Biology Assessment of Human Blood to Monitor Immune Responses after Influenza Vaccination

@inproceedings{Hoek2015ACS,
  title={A Cell-Based Systems Biology Assessment of Human Blood to Monitor Immune Responses after Influenza Vaccination},
  author={Kristen L. Hoek and Parimal Samir and Leigh M Howard and Xinnan Niu and Nripesh Prasad and Allison C Galassie and Qi Liu and Tara M. Allos and Kyle A. Floyd and Yan Guo and Yu Shyr and Shawn E. Levy and Sebastian Joyce and Kathryn Margaret Edwards and Andrew J. Link},
  booktitle={PloS one},
  year={2015}
}
Systems biology is an approach to comprehensively study complex interactions within a biological system. Most published systems vaccinology studies have utilized whole blood or peripheral blood mononuclear cells (PBMC) to monitor the immune response after vaccination. Because human blood is comprised of multiple hematopoietic cell types, the potential for masking responses of under-represented cell populations is increased when analyzing whole blood or PBMC. To investigate the contribution of… CONTINUE READING

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