A Cell-Based High-Throughput Screen for Novel Chemical Inducers of Fetal Hemoglobin for Treatment of Hemoglobinopathies

Abstract

Decades of research have established that the most effective treatment for sickle cell disease (SCD) is increased fetal hemoglobin (HbF). Identification of a drug specific for inducing γ-globin expression in pediatric and adult patients, with minimal off-target effects, continues to be an elusive goal. One hurdle has been an assay amenable to a high… (More)
DOI: 10.1371/journal.pone.0107006

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@inproceedings{Peterson2014ACH, title={A Cell-Based High-Throughput Screen for Novel Chemical Inducers of Fetal Hemoglobin for Treatment of Hemoglobinopathies}, author={Kenneth R. Peterson and Fl{\'a}via Costa and Halyna Fedosyuk and Renee Y. Neades and Allen M. Chazelle and Lesya V. Zelenchuk and Andrea H. Fonteles and Parmita Dalal and Anuradha Roy and Rathnam Chaguturu and Biaoru Li and Betty S Pace}, booktitle={PloS one}, year={2014} }