A Cdc42 ortholog is required for penetration and virulence of Magnaporthe grisea.

@article{Zheng2009ACO,
  title={A Cdc42 ortholog is required for penetration and virulence of Magnaporthe grisea.},
  author={Wu Zheng and Zhiying Zhao and Ji-sheng Chen and Wende Liu and Haiyan Ke and Kwok-Yung Yuen and Guodong Lu and Alan G. Darvill and Peter Albersheim and Shengcheng Wu and Zonghua Wang},
  journal={Fungal genetics and biology : FG & B},
  year={2009},
  volume={46 6-7},
  pages={450-60}
}
Cdc42, a member of the Rho-family small GTP-binding proteins, is a pivotal signaling switch that cycles between active GTP-bound and inactive GDP-bound forms, controlling actin cytoskeleton organization and cell polarity. In this report, we show that MgCdc42, a Cdc42 ortholog in Magnaporthe grisea, is required for its plant penetration. Consequently, the deletion mutants show dramatically decreased virulence to rice due to the arrest of penetration and infectious growth, which may be attributed… CONTINUE READING

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