A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.

@article{Swaminathan2014ACA,
  title={A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.},
  author={Karthic Swaminathan and Annette Mueller-Taubenberger and Jan Faix and Francisco Rivero and Angelika A. Noegel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 1},
  pages={
          E25-33
        }
}
The Cdc42- and Rac-interactive binding motif (CRIB) of coronin binds to Rho GTPases with a preference for GDP-loaded Rac. Mutation of the Cdc42- and Rac-interactive binding motif abrogates Rac binding. This results in increased 1evels of activated Rac in coronin-deficient Dictyostelium cells (corA(-)), which impacts myosin II assembly. corA(-) cells show increased accumulation of myosin II in the cortex of growth-phase cells. Myosin II assembly is regulated by myosin heavy chain kinase-mediated… CONTINUE READING
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Rho Signaling in Dictyostelium discoideum.

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