A Cation–π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels

@article{Ahern2006ACI,
  title={A Cation–π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels},
  author={Christopher A. Ahern and Amy L. Eastwood and Henry A. Lester and Dennis A Dougherty and Richard Horn},
  journal={The Journal of General Physiology},
  year={2006},
  volume={128},
  pages={649 - 657}
}
Open-channel blockers such as tetraethylammonium (TEA) have a long history as probes of the permeation pathway of ion channels. High affinity blockade by extracellular TEA requires the presence of an aromatic amino acid at a position that sits at the external entrance of the permeation pathway (residue 449 in the eukaryotic voltage-gated potassium channel Shaker). We investigated whether a cation-pi interaction between TEA and such an aromatic residue contributes to TEA block using the in vivo… CONTINUE READING

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Palmer served as editor

G Lawrence
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