A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy

  title={A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy},
  author={Denise Hilfiker-Kleiner and Karol Adam Kaminski and Edith Katharina Podewski and Tomasz Andrzej Bonda and Arnd Schaefer and Karen Sliwa and Olaf Forster and A. C. Quint and Ulf Landmesser and Carola Doerries and Maren Luchtefeld and Valeria Poli and Michael H. Schneider and Jean-Luc Balligand and Fanny Desjardins and A Sameer Ansari and Ingrid Struman and Ngoc Q.N. Nguyen and Nils Holger Zschemisch and G. O. Klein and Gerd Heusch and Rainer Schulz and Andres Hilfiker and Helmut Drexler},
Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-specific deletion of stat3 develop PPCM. In these mice, cardiac cathepsin D (CD) expression and activity is enhanced and associated with the generation of a cleaved antiangiogenic and proapoptotic 16 kDa form of the nursing hormone prolactin. Treatment with bromocriptine, an inhibitor of prolactin secretion, prevents… CONTINUE READING
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