[A Case of Pathologically Complete Response of a Rectal Cancer after Preoperative Treatment with mFOLFOX6 and Radiation Therapy].

Abstract

A 60-year-old man who had bloody stools after sigmoid colonoscopy was admitted to our hospital. A digital examination and sigmoid colonoscopy showed a type 2 circular tumor at location Rb with incomplete mobility and tumor hemorrhage, and the result of a biopsy was moderately differentiated adenocarcinoma (tub2). Computed tomography and magnetic resonance imaging suggested a possibility of invasion of the primary rectal tumor to the sacrum. The clinical stage was cT4bN0M0H0P0, cStage Ⅱ, which is generally not treatable by surgery. Sigmoid colostomy was performed, and a central venous port was implanted. After a preoperative treatment consisting of 3 courses of mFOLFOX6 and radiation therapy, the clinical stage changed to ycT2N0M0H0P0, ycStageⅠ. Super-low anterior resection and covering ileostomy were performed 46 days after the preoperative treatment. A pathological examination revealed no residual cancer cells in the primary lesion and lymph node (Grade 3, pCR). The patient has been disease-free for 4 years and 9 months after the operation.

Cite this paper

@article{Note2015ACO, title={[A Case of Pathologically Complete Response of a Rectal Cancer after Preoperative Treatment with mFOLFOX6 and Radiation Therapy].}, author={Hiromasa Note and Shinichiro Shimizu and Takashi Ariga and Keisuke Suzuki and Hiroshi Kobayashi and Naoto Sawada and Yoko Kanada and Yoshihide Senba and Takafumi Yoshioka and Yayoi Sato and Akinari Miyazaki and Toshiyuki Natsume and Hiroshi Matsuzaki and Hajime Tanaka and Takashi Maruyama}, journal={Gan to kagaku ryoho. Cancer & chemotherapy}, year={2015}, volume={42 12}, pages={1472-4} }