some burning sensation and griping pain in his abdomen. In spite of it he took 2 more tablets in the noon and 2 in the night. As a consequence he had a very restless night, passing frequent tarry stools with intense burning and griping in his abdomen. The urine became scanty, high coloured and thick, there was burning of hands and feet and also slight perspiration over his forehead. He stopped taking further the paludrine tablets and went on taking plenty of plain water as well as liquid diet. The intensity of troubles lasted for three days even after the stoppage of the drug, and it took about a week to be free from all troubles.