A Case Report of Propofol Dependence in a Physician

  title={A Case Report of Propofol Dependence in a Physician},
  author={U. Bonnet and J. Harkener and N. Scherbaum},
  journal={Journal of Psychoactive Drugs},
  pages={215 - 217}
  • U. Bonnet, J. Harkener, N. Scherbaum
  • Published 2008
  • Medicine
  • Journal of Psychoactive Drugs
  • Abstract Propofol is a widely used general anaesthetic with multisite mechanisms and especially ultrashort activation of certain central GABA-A receptors. Since its introduction into the market in the mid 1980s this is the seventh report on propofol dependence in the literature. The present case shows for the first time that craving for propofol can be quite intense and able to induce addictive behaviour. 
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    Self-administration of propofol is mediated by dopamine D1 receptors in nucleus accumbens in rats
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