A Case Report of Malignant Infantile Osteopetrosis

  title={A Case Report of Malignant Infantile Osteopetrosis},
  author={Merve Usta and Seda Geylani Gulec and Serap Karaman and Ela Erdem and Hicran Emral and Nafiye Urgancı},
  booktitle={Iranian journal of pediatrics},
BACKGROUND Malignant infantile osteopetrosis (MIOP) presents early in life with extreme sclerosis of the skeleton and reduction of bone marrow spaces. Since there is a defect in the bone marrow, the disease can cause anemia, extramedullary hematopoiesis secondary to anemia leading to hepatosplenomegaly, cranial nerves compression and severe growth failure. This disorder is often lethal within the first decade of life because of secondary infections. Stem cell transplantation (SCT) remains the… CONTINUE READING


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