A Cascade of Protein Kinase C Isozymes Promotes Cytoskeletal Polarization in T Cells

@inproceedings{Quann2011ACO,
  title={A Cascade of Protein Kinase C Isozymes Promotes Cytoskeletal Polarization in T Cells},
  author={Emily J. Quann and Xin Liu and Gr{\'e}goire Altan-Bonnet and Morgan Huse},
  booktitle={Nature Immunology},
  year={2011}
}
Polarization of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell (APC) is driven by the accumulation of diacylglycerol (DAG) at the immunological synapse (IS). The mechanisms that couple DAG to the MTOC are not known. By single-cell photoactivation of the T cell antigen receptor (TCR), we found that three distinct isoforms of protein kinase C (PKC) were recruited by DAG to the IS in two steps. PKC-ɛ and PKC-η accumulated first in a broad region of membrane… CONTINUE READING
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